Synthesis and Biological Evaluation of New Salicylate Macrolactones from Anacardic Acids
نویسندگان
چکیده
Lúcio P. L. Logrado, Dâmaris Silveira, Luiz A. S. Romeiro, Manoel O. de Moraes, Bruno C. Cavalcanti , Letícia V. Costa-Lotufo , Cláudia do Ó Pessoa d and Maria Lucilia dos Santos* Laboratório de Isolamento e Transformação de Moléculas Orgânicas, Instituto de Química and Faculdade de Ciências da Saúde, Universidade de Brasília, Campus Darcy Ribeiro, 70904-970 Brasília – DF, Brazil Núcleo de Química Bioorgânica e Medicinal, Universidade Católica de Brasília, 71966-700 Taguatinga – DF, Brazil
منابع مشابه
Synthesis of anacardic acids, 6-[8(Z),11(Z)-pentadecadienyl]salicylic acid and 6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid.
11-Chloro-3-methoxy-2-undecenal was synthesized from 8-bromooctanol, and an annelation reaction with this aldehyde and ethyl acetoacetate proceeded to give the ethyl 6-(8-chlorooctyl)salicylate. Ethyl 6-(8-chlorooctyl)salicylate was converted to ethyl 6-(7-formylheptyl)-2-methoxybenzoate through the iodide after protection of the phenolic hydroxyl group. Finally, the Wittig reaction with the al...
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